Briefly, our experiments indicated that VNP-pN-FADD and VNP-pN-N-FADD likely suppressed tumor growth and improved survival of melanoma-bearing mice by inducing apoptosis of tumor cells through caspase-dependent cell death pathway, and VNP-pN-N-FADD induced more cleavage of caspase-3 than VNP-pN-FADD, thus VNP-pN-N-FADD displaying a more potent antitumor efficacy than VNP-pN-FADD. Here, CASP3 is linked to neoplasm.