Although carrying plasmids declined tumor target of VNP slightly, there were no significant differences among VNP, VNP-pN, VNP-pN-FADD and VNP-pN-N-FADD in vivo distribution, suggesting that the expression of exogenous proteins didn’t significantly affect the growth and tumor targeting abilities of VNP20009 (P > 0.05). Here, FADD is linked to neoplasm.