FADD and neoplasm: In the present study, a mutant of mouse FADD (m-FADD, 1–181 aa), which is truncated of the C-terminal tail (m-FADD, 182–205 aa) similar to human N-FADD (h-FADD, 1–182 aa), was constructed and VNP20009 was engineered to express FADD or N-FADD (VNP-pN-FADD, VNP-pN-N-FADD) under the control of a hypoxia-induced NirB promoter in tumor tissues.