Western blotting results showed that FADD and N-FADD proteins were expressed in tumor tissues treated by VNP-pN-FADD or VNP-pN-N-FADD, but were not detected in the VNP and VNP-pN groups, indicating that the NirB-driven expressions of exogenous FADD and N-FADD were successfully expressed at the same level in tumor tissues (Fig. 4D,E). The gene discussed is FADD; the disease is neoplasm.