As apoptosis deficiency resulting in therapy resistance of melanoma, it is highly suggestive for restoring and strengthening apoptosis in treatment of melanoma2, 17, for example, Venza et al. found the histone deacetylase inhibitor MS-275 synergized with TRAIL could induce apoptosis in TRAIL-resistant cell lines by decreasing c-FLIP which providing a promising therapeutic approach for treatment of melanoma18. The gene discussed is CFLAR; the disease is melanoma.