CTLA4 and neoplasm: Photographs of India-ink stained whole lungs harvested at different days also confirmed that different from all control groups in which many metastatic tumour nodules were found in the mouse lung, no noticeable sign of lung metastasis was noted in the last group with PLGA-ICG-R837-based PTT combined with anti-CTLA-4 therapy (Supplementary Fig. 8).