CD44 and neoplasm: It was found that the percentage of TEM cells (CD3+CD8+CD62L-CD44+) was much higher in the group of mice with their primary tumour removed by PLGA-ICG-R837-based PTT (Fig. 5c), whereas the percentage of TCM cells (CD3+CD8+CD62L+CD44+) that are less important for immune memory decreased after PLGA-ICG-R837-based PTT together with anti-CTLA treatment in the first round (Supplementary Fig. 12).