After i.v. injection with PLGA-PEG-ICG-R837 (6 mg kg−1 R837, 8 mg kg−1 ICG) for 24 h, CT26-tumour-bearing mice were irradiated by the 808 nm laser for 10 min (0.8 W cm−2), which led to the rise of tumour surface temperature to ∼52 °C (Fig. 6d,e). The gene discussed is DDX53; the disease is neoplasm.