For this reason and, concerned that the chance of β cell recovery was diminishing with increasing duration of hyperglycemia, on day 47 a decision was made to increase the frequency of glargine injections to 8-hourly, with a slight increase total daily dose of insulin (to 5.5–7 units per day; 1.5–2.5 units per injection). Here, INS is linked to Hyperglycemia.