Accordingly, Tchou and colleagues observed different gene expression profiles (particularly in pathways associated with cytoskeleton, integrin signalling and metastasis) among early passage primary CAFs derived from three main subtypes (ER+, triple negative and Her2+) of human breast cancer samples, suggesting that CAFs gene expression profile might be a useful marker in breast cancer prognosis [248]. This evidence concerns the gene ERBB2 and breast cancer.