Some of these molecules secreted by adipocytes are involved in the regulation of body weight (leptin, adiponectin), in the local inflammation generated in obesity (TNF-α, IL-6, and IL-1β), in vascular function (Ang II and PAI-1), or in breeding (estrogens, among others). Here, SERPINE1 is linked to obesity due to melanocortin 4 receptor deficiency.