The resulting activation/phosphorylation of CREB and recruitment of CREB-binding protein (CBP) along with other transcriptional components enables transcription of specific CREB target genes, including those implicated in long-term memory and plasticity as well as in the development of anxiety-like and alcohol-drinking behaviors, such as the neuropeptide Y (NPY) and the brain-derived neurotrophic factor (BDNF) (61–64). The gene discussed is CREB1; the disease is Anxiety.