The failure of peptide vaccination to induce HER2-specific CD8+ T cell recognition may be due to overexpression of HER2 causing reduced levels of major histocompatibility complex (MHC) class I, and decreased number of molecules of the antigen processing and presenting machinery (APM), allowing tumor escape from immunosurveillance (Mimura et al., 2011). Here, ERBB2 is linked to neoplasm.