In addition to one or both of these mechanisms regulating platelet production, hepatocytes can be induced to produce additional thrombopoietin when stimulated by interleukin 6 [8], the mechanism of thrombocytosis seen in patients with chronic inflammatory conditions, such as ulcerative colitis or rheumatoid arthritis, the two most common causes of thrombocytosis. Here, THPO is linked to thrombocytosis disease.