VWF and von Willebrand disease (hereditary or acquired): Eleven different previously reported mutations of the VWF gene based on the ISTH-SSC VWF database, as accessed in June 2016, was identified in the 16 index patients with type 2 VWD including 6 mutations from 8 type 2A VWD patients: p.Arg1374His, p.Ser1506Leu, p.Cys1272Gly, p.Arg1597Trp, p.Cys1272Arg and p.Ile1628Thr; 3 mutations from 5 type 2B VWD patients: p.Arg1306Trp, p.Val1316Met and p.Arg1308Cys; and 2 mutations from 3 type 2M VWD patients: p.Arg1374Cys and p.Arg1315Cys.