VWF and von Willebrand disease (hereditary or acquired): Six different novel mutations of the VWF gene also according to the ISTH-SSC VWF database was identified in the 7 index patients with type 2 VWD including 3 mutations from 3 type 2A VWD patients: p.Leu1696del, p.Glu1519del and p.Ala1500Val; and 3 mutations from 4 type 2M VWD patients: c.5312-1 ~ −2del AG, p.Leu1276Arg and c.3538 + 1G → C.