Recently, several separate genome-wide association scans have demonstrated that common SNPs, including those in the leucine rich repeat and fibronectin type III domain containing 2 (LRFN2), cyclin-dependent kinase inhibitor 1A (CDKN1A), brain-specific angiogenesis inhibitor 3 (BAI3), and parkin RBR E3 ubiquitin protein ligase (PARK2) genes, are associated with LC prognosis. Here, ADGRB3 is linked to laryngotracheoesophageal cleft.