To further confirm the observation we've made from tissue level, we've also detected the M2 macrophages in peripheral blood sampled from patients with glioma as well as from normal healthy controls, by means of evaluation of the ratio of macrophage positive for CD168, M2 macrophage marker, to leukocyte positive for CD45, pan-leukocyte marker (Supplementary Figure S2A). Here, HMMR is linked to glioma.