Moreover, results of IHC detection showed that M2 macrophages were existed in the tumor lesions dissected from nude mice co-inoculation with M2 macrophages, whereas M2 macrophages were hardly detectable in tumor lesions from nude mice co-inoculation with THP-1 cells treated with M-CSF alone (Figure 4C). The gene discussed is CSF1; the disease is neoplasm.