IL10 and neoplasm: Secondly, we found that tumorigenesis of glioma was dependent on tumor-promoting roles of M2 macrophage; thirdly, IL-10, secreted by M2 macrophage, was shown to be able to promote tumorigenesis and that block of IL-10 can markedly abolish the influence over proliferation of glioma cells exerted by M2 macrophage, demonstrating that IL-10 can be potentially used as therapeutic target in the therapy of glioma.