STAT3 and central nervous system cancer: Moreover, M2 macrophages were displayed to be able to promote the proliferation and tumorigenesis of glioma cells in vitro and in vivo through secretion of IL-10 which was dependent on the activation of JAK2/STAT3 signaling pathway, indicating that IL-10, secreted from M2 macrophage, can be targeted in the curing of patients with glioma.