Having found that IL-10 secreted from M2 macrophages was dependent on the JAK2/STAT3 signaling pathway and that co-culture with glioma cells was able to activate the JAK2/STAT3 signaling pathway in M2 macrophages, we've next tried to understand how IL-10 was dependent on JAK2/STAT3 pathway. Here, STAT3 is linked to central nervous system cancer.