It was found that both p-AKT, p-STAT3, p-JAK2 and p-ERK1/2 were increasingly activated in U271 and U87 cell after co-culture with M2 macrophage (Figure 5B), indicating that glioma cells U271 and U87 could activate the JAK2/STAT3 signaling pathway in M2 macrophages, which in turn M2 macrophages could also activate both the ERK1/2 and AKT signaling pathway in glioma cells. Here, MAPK3 is linked to glioma.