It was found that IL-10 was shown to be remarkably up-regulated in glioma tissues compared with paired normal control tissues and that IL-10 was also significantly associated with poorer overall survival (Supplementary Figure S4E) and that up-regulation of IL-10 was also pronouncedly correlated with WHO grade and relapse of patients with glioma (Table 3). Here, IL10 is linked to central nervous system cancer.