Using quantitative real time-polymerase chain reaction (qRT-PCR) assay, we demonstrated that HIF-1α and DEC1 mRNA (see below) levels were increased but c-Myc and ASS1 mRNA were reduced in SCLC cells treated with cDDP (Figure 2E), consistent with the protein expression patterns (Figure 2A). The gene discussed is HIF1A; the disease is small cell lung carcinoma.