TP53 and lung large cell carcinoma: We evaluated the anti-cancer effects of SFE using both kinds of lung cancer cells (A549, NSCLC; H460, large cell lung cancer; H446, SCLC; HCC827, adenocarcinoma/NSCLC; H1975, adenocarcinoma/NSCLC and H1299, NSCLC/TP53 null) and found similar activities of SFE for these cells.