Proliferation was significantly reduced with tumours from placebo treated mice containing 247.8 +/− 29.25 Ki67 positive cells per mm2, this was reduced in tumours from mice receiving anakinra via the treatment protocol to 207.21 +/− 10.38 cells per mm2 (P < 0.01) and to 134.65 +/− 36.08 in tumours from mice administered anakinra using the preventative protocol (P < 0.001) (Figure 5e and 5g). This evidence concerns the gene MKI67 and neoplasm.