Furthermore, forced expression of p70S6K1 in miR-145-over-expressing pancreatic adenocarcinoma cells restored the expression levels of HIF-1α and VEGF which were inhibited by miR-145, suggesting that miR-145 controls expression of HIF-1a and VEGF by targeting p70S6K1 in the cells. This evidence concerns the gene VEGFA and pancreatic adenocarcinoma.