H1-2 and hepatocellular carcinoma: In hepatocellular carcinoma, HIST1H1C a gene involved in regulating higher order chromatin structures, may serve to maintain DNA methylation patterns.[34] Because our identified genes are part of the hypoxia response, and hypoxia is associated with aggressiveness in cancer [6, 35], these genes may play a role in increasing resistance to chemotherapy and/or promoting primary tumor growth and metastasis.