PRKDC and neoplasm: First, DNA-PKcs inhibition or shRNA knockdown dramatically potentiated salinomycin-induced OS cell death and apoptosis; Second, expression of miR-101, an anti-DNA-PKcs miRNA [26, 36], downregulated DNA-PKcs and augmented salinomycin's lethality in OS cells; Third, forced-expression of DNA-PKcs in OS cells inhibited salinomycin's cytotoxicity; Fourth, salinomycin-mediated anti-tumor activity in vivo was dramatically sensitized with co-administration of DNA-PKcs inhibitor NU7026.