EDN1 and acute respiratory distress syndrome: We demonstrated that CsnB, an agonist of Nur77, decreased pulmonary neutrophilic inflammation and ET-1 expression and attenuated alveolar capillary barrier dysfunction, resulting in alleviation of hypoxemia and improvement of lung, liver, and kidney injury in LPS-induced ARDS rats, whereas, C-DIM8, a pharmacological inactivator of Nur77, exhibited neither influence on ET-1 regulation nor therapeutic effects in ARDS rats.