By down-regulating the expression of Secreted Protein, Acidic and Rich in Cysteine (SPARC), TF sex determining region Y-box 5 (SOX-5) functions in the progression of NPC and may be used as a predictor for poor NPC prognosis.14, 15 Although these studies have been performed to investigate NPC, the mechanisms of NPC still remain unclear. This evidence concerns the gene SPARC and nasopharyngeal carcinoma.