ZIC2 expression is up-regulated in several malignant tumors, including synovial sarcoma, pediatric medulloblastoma and endometrial cancers.36, 37, 38 Therefore, the expression levels of FN1, CXCL9 and ZIC2 might be correlated with NPC. The gene discussed is CXCL9; the disease is nasopharyngeal carcinoma.