BMI1 and acute myeloid leukemia: A previous study showed that the oncogene Bmi-1 is a direct target gene of Sall4B, where Sall4B expression strongly correlates with Bmi-1 in primary acute myeloid leukemia (AML) and high levels of H3–K4 trimethylation and H3–K79 dimethylation were observed in the Sall4B binding region of the Bmi-1 promoter [22].