MTOR and Anxiety: Interestingly, blocking the mTOR pathway by intracerebroventricular infusion of rapamycin could inhibit the rapid antidepressant activity of ketamine [34], whereas chronic and partial inhibition of mTOR by rapamycin could reduce anxiety and depressive-like behavior in mice throughout their lifespan, possibly by stimulating the production of major monoamines (norepinephrine, dopamine and 5-hydroxytrptamine) [33].