PAECs treated with MPs from 8-week PAH rats also exhibited a two-fold increase in ICAM-1 in permeabilized cells (whole cell ICAM-1) compared to those treated with MPs from 8-week control rats, and further, no whole cell change in ICAM-1 was detected with 3-week MPs (Fig. 2c and d). The gene discussed is ICAM1; the disease is pulmonary arterial hypertension.