Rigosertib-dependent translocation of p-ATF-2 occurred in HNSCC independent of HPV status, but did not occur in Normal Human Dermal Microvascular Endothelial Cells (HMVEC-d), suggesting that rigosertib-induced translocation of ATF-2 may be specific to tumor cells (Figure 5B). The gene discussed is ATF2; the disease is head and neck squamous cell carcinoma.