TGFβR1 can phosphorylate the transcription factors Smad2 and Smad3, which can regulate the expression of down stream signaling genes, such as p21 and C-myc et al. In breast cancer cells, the binding of 14-3-3ζ protects TGFβR1 from degradation [13]. This evidence concerns the gene TGFBR1 and breast cancer.