Multiplicity of metastatic tumors (P=0.002; relative risk=7.145; 95% confidence interval=2.015-25.337) and reduced osteoprotegerin expression (P=0.012; relative risk=5.425; 95% confidence interval=1.443-20.397) were independently predicted recurrent liver metastasis in our study group. Here, TNFRSF11B is linked to metastatic neoplasm.