We observed significant inverse relationships between osteoprotegerin expression and multiplicity of metastatic tumors (P<0.001), bilobar involvement of metastatic tumors (P=0.046), higher histological grade of primary colorectal carcinoma (P<0.001), and occurrence of recurrent liver metastasis (P<0.001). Here, TNFRSF11B is linked to colorectal carcinoma.