A univariate survival analysis showed that the multiplicity of metastatic tumors (P<0.001), bilobar involvement of metastatic tumors (P=0.002), recurrent liver metastasis (P<0.001), and reduced osteoprotegerin expression (P<0.001) were significant predictors of poor prognosis (Table 4). Here, TNFRSF11B is linked to metastatic neoplasm.