PTK2 and cancer: miR-7 has been reported to suppress the key numbers of cancer cell signaling pathway, including EGFR/Ras/Raf/MEK/ERK1/2, EGFR/PI3K/Akt/mTOR, IGF1R/IRS, Integrin/FAK, Rac1/Pak1 and Ack1-mediated signaling transduction, which may implicated in tumorigenesis, progression and metastasis [18].