Ninety six hours post transfection the relative survival of bladder cancer cells depleted of either all isoforms of RECQL5 (si1) or specifically RECQL5β (si2) was significantly reduced (Student's t-test, p value = 5.1 × 10−3 and 3.5 × 10−3 respectively), while the survival of normal bladder cells was not affected (Figure 3B), suggesting that RECQL5 could be a cancer specific target for therapeutic intervention in UCC. The gene discussed is RECQL5; the disease is urinary bladder carcinoma.