To determine the mechanism by which miR-451 regulates cell apoptosis and proliferation in AML cells, we tried to identify the potential targets of miR-451 via several prediction programs and noticed that 3'UTR of YWHAZ mRNA contains the sequence motif that could match well with the “seed sequence” of miR-451 (Figure 5A). Here, YWHAZ is linked to acute myeloid leukemia.