Although our results show that MYCN overexpression slightly up-regulates miR-2110 in one of the investigated cell lines, the significant negative correlation between MYCN mRNA and miR-2110 levels in neuroblastoma specimens suggest that the regulation of MYCN expression by miR-2110 is the main stream in the interaction between MYCN and miR-2110, whereas the regulation of miR-2110 by MYCN does not play a significant role in determining the correlation between their expressions. The gene discussed is MYCN; the disease is neuroblastoma.