Expression levels of serum CEA, CD133+CD44+CD54+ cellular subpopulation and extranodal tumor deposits showed predictive value for liver metastasis (P<0.05), and the odds ratios are 3.352 (95%C.I., 1.824–6.839), 2.898 (95%C.I.1.374–6.110), 25.820 (95%C.I.5.155–129.322), respectively. The gene discussed is PROM1; the disease is neoplasm.