Since DcR3 overexpression altered RKO and HT29 cell morphology such that both cell lines exhibited a spindle-like, fibroblastic cell morphology (Figure 4A), and high DcR3 expression levels were correlated with CRC metastasis in humans (Supplementary Table S1), we hypothesized that DcR3 participates in the epithelial-mesenchymal transition (EMT) of CRC cells, which is a key event associated with tumor invasion and metastasis [14–16]. This evidence concerns the gene TNFRSF6B and neoplasm.