To further confirm the impact of DcR3 expression on CRC cell proliferation and migration in vitro, we performed lentiviral vector-mediated shRNA knockdown of DcR3 in SW480/M5 and HCT116 cells (Supplementary Figure S1A) and carried out colony formation assays and CCK8 proliferation assays to detect CRC cell proliferation. Here, TNFRSF6B is linked to colorectal carcinoma.