Whether these effects are translated through the same EREs identified in this study is not known but our results indicate that a similar estrogen up-regulation of SEMA3B and 3F expression is also taking place in breast cancer cells, and is consistent with the positive correlation we found between ESR1 and SEMA3B or SEMA3F in human breast tumors using METABRIC dataset. Here, ESR1 is linked to breast cancer.