We have previously shown a direct molecular and functional interplay between FGF-2 and PDGF family members, by demonstrating that such ligands interact with high affinity, inducing hetero-dimerization of the corresponding receptors [30], leading to a relevant inhibition of cell growth in both endothelial [55] and melanoma cells, either in vitro and in vivo mouse melanoma models [56]. This evidence concerns the gene FGF2 and melanoma.