Besides, overexpressed ZNF703 could even induce the gene expression of lymphoid enhancer-binding factor 1 (LEF1), transcription factor 12 (TCF12), wingless-type MMTV integration site family, member 4 (WNT4) and achaete-scute complex-like 1 (ASCL1) that related to the WNT or NOTCH signaling pathways, to regulate the activity of breast cancer stem cells [16]. Here, LEF1 is linked to breast carcinoma.