Hence, QBC939 and RBE cell lines were selected for further investigations to explore whether ZNF703 could change the cell motility in CCA, in which ZNF703 were inhibited or overexpressed through RNA interference technology, for their high or low level of endogenous ZNF703 expression, proliferation and invasion capability, respectively.(Figure 2B and 2C). This evidence concerns the gene ZNF703 and cholangiocarcinoma.