Studies had confirmed that ZNF703 as a co-factor of a nuclear complex comprising DDB1 and CUL4 associated factor 7 (DCAF7), prohibitin 2 (PHB2) and nuclear receptor corepressor 2 (NCOR2) could inhibit the transcription of relative genes, regulating cell proliferation, differentiation and cell cycle, finally activate the stem cell-related genes and promote cancer stem cells in luminal B breast cancer [14]. The gene discussed is PHB2; the disease is breast cancer.