In general, ZNF703 may act as a transcriptional repressor and affect target genes which mediate various aspects of cancer pathophysiology, such as epithelial-mesenchymal transition, adhesion, motility, proliferation and cancer stem cell renewal, CDH1, cadherin-1, CTTND1, p120-catenin and TGFBR2 [10, 26, 29–31]. Here, CDH1 is linked to cancer.