ALDH1A1 knockdown has been shown to decrease the pro-tumorigenic and pro-metastatic advantage of melanoma cells lacking dioxin receptor expression, decreasing not only their migration and invasion potentials, but also the percentage of CD133+CD29+CD44+ cells, melanosphere size and expression of the pluripotency marker SOX2 [32]. The gene discussed is ITGB1; the disease is melanoma.