This finding suggested that tumor anti-PD-L1 levels triggered the effect on the immune system providing an increment of OVA-CD8+ lymphocytes, which were characterized by a rapid and discrete increment at 10 min, 16.85%, declining very fast until 11.98% at 1 h and increasing again at 8 h, 39.98%, after antibody administration. The gene discussed is CD8A; the disease is neoplasm.