Interestingly, the increased expression levels of Aurora-A mRNA and PTGS2 mRNA in different stages of CRC tissues were not statistically significant (Supplementary Figure S5A), whereas gradually increased Aurora-A mRNA expression was noted from normal mucosa, colon polyps to CRC tissues (Table 1 and Supplementary Figure S5B). This evidence concerns the gene PTGS2 and colon inflammatory polyp.