CDC42 and neoplasm: The silenced expression of miR-137 in the early stage of carcinogenesis may contribute to the neoplastic growth through the action of Aurora-A, whereas in the late stage of carcinogenesis, the loss of miR-137 expression can promote cancer cell metastasis by the increased expression of CDC42. Using the xenograft animal model, we demonstrated that the enforced expression of miR-137 can inhibit tumor growth, and the expression of Aurora-A in miR-137-expressing tumor tissues is repressed (Figure 6 and Supplementary Figure S10).