To determine whether H2B-IFI16 associate during EBV latent infection, EBV (-) BJAB, and EBV (+) LCL (latency III) and EBV (+) Akata (latency I) cells were subjected to IFA using anti-IFI16, H2B and BRCA1 antibodies. This evidence concerns the gene H2BC21 and disease arising from reactivation of latent virus.