Furthermore, colocalization of H2B+STING PLA spots with IFI16+H2B and BRCA1+H2B spots (Fig 6A and 6B, yellow spots and red arrows) suggested that the macromolecular complex formed between IFI16+H2B+BRCA1 is in close proximity with STING in the cytoplasm after infection. Here, H2BC21 is linked to infection.