This is also consistent with reported frequencies of lower CD99 expression in ~15% of childhood T-ALL cases.[16] While CD99 gene expression was not significantly higher, in a smaller cohort of patients, compared to normal BM samples, genes for other leukemia associated phenotype markers used in the EuroFlow FCM T-ALL MRD panels, including CD2 and CD5, were overexpressed in these cases.[15] Gene expression analyses of LPC are extremely challenging, due to limiting cell numbers and this study represents the first report on WGA analyses in T-ALL LPC populations. This evidence concerns the gene CD2 and leukemia.