Our IP studies demonstrating the co-immunoprecipitation of Tsg101 with EphA2R during KSHV de novo infection with a little such interaction in the uninfected cells, together with the increased PLA Tsg101 and EphA2R dots denoting the close proximity and increased interactions of Tsg101 and EphA2R are suggestive of interactions on the cytoplasmic side of the macropinosome. Here, TSG101 is linked to infection.