Although EGFR signaling and cell proliferation, as represented by nuclear EGR1 and MKI67, were significantly induced in AGR2+/- mice with pancreatitis on Day 1, the levels were 65% and 75% lower, respectively, than wild-type AGR2+/+ mice (Fig 5B and 5C). This evidence concerns the gene EGR1 and pancreatitis.