Four pancreatic cancer cell lines were examined for their basal expression of epithelial (E-cadherin, ZO-1) and mesenchymal markers (N-cadherin), as well as transcriptional repressors of E-cadherin (Snail-1 and Zeb-1) (Fig 1A–1E). This evidence concerns the gene TJP1 and familial pancreatic carcinoma.