Four pancreatic cancer cell lines were examined for their basal expression of epithelial (E-cadherin, ZO-1) and mesenchymal markers (N-cadherin), as well as transcriptional repressors of E-cadherin (Snail-1 and Zeb-1) (Fig 1A–1E). The gene discussed is ZEB1; the disease is familial pancreatic carcinoma.