Our gene expression analysis suggests T lymphocytes differentiation in T1R refers to Th1 phenotype, with an increased expression of TBX21, while, in non-reactional BL form, it relates to Th2 through an increase of STAT6 and GATA3. One should not rule out the participation of Treg among non-reactional BL patients, as FOXP3 expression was significantly increased in this group, in comparison with T1R patients (p<0.05; Fig 4D). The gene discussed is TBX21; the disease is Burkitt lymphoma.