Monosomy 3 in uveal melanoma is associated with loss of BAP1 (BRCA1 associated protein-1; chr3p), [8,48], which is connected to PRC2 (of which EZH2 is a member) through ASXL1(additional sex combs-like transcriptional regulator 1) [49,50]. The gene discussed is EZH2; the disease is uveal melanoma.