When we compared expression of these HLA transcriptional regulators with HLA expression in tissue of human uveal melanoma, we observed that the gene-expression levels of the HLA transcriptional activators IRF1 and IRF8 correlated positively with HLA class I and B2M, NLRC5 with HLA-B and B2M expression, and CIITA with HLA-B as well as with B2M (Table 2). The gene discussed is IRF1; the disease is uveal melanoma.