It is well known that HF is associated with hemodynamic changes, such as reduction of blood pressure levels and increased systemic vascular resistance, depending in a large part on cardiac pump dysfunction.16 In the present report, we explored whether BAG3 has nitric oxide (NO) vasorelaxant effects; it was our hypothesis that the protein would regulate vascular tone and mediate blood pressure. Here, BAG3 is linked to hydrops fetalis.