These results are contradictory with the previously proposed role of PKN2 in apoptosis induced by Fas ligation, anti-fungal or anti-cancer drugs.39 It has been reported that PKN2 is cleaved at AA700 by caspases into the C-terminal fragment comprising AA700-984 which interacts with and inhibits AKT.31 Since we failed to observe any apoptotic effects when the full-length PKN2 or the C-terminal fragments of PKN2 were overexpressed in C2C12 cells, this apoptotic effect of PKN2 might be cell type- or cellular context-dependent. This evidence concerns the gene FAS and cancer.