Interestingly, paxilline also induces the proliferation of some cancer cells expressing KCa1.1.58 However, in other tissues, blocking KCa1.1 and other potassium channels inhibits proliferation.13, 19, 42, 50 This discrepancy between tissues underlines a differential role of these channels dependent on the different signaling pathways that lead to cell proliferation. The gene discussed is KCNA3; the disease is cancer.