DM1 is considered an RNA-mediated disease, with the pathogenesis of this disease in large part from dysregulation of alternative splicing programs.47, 48, 49 KCa1.1 α contains multiple alternating splicing sites with more than 30 splice variants identified in different tissues and species.16, 50, 51 Alternative splicing of KCa1.1 α can affect not only the potassium-conducting properties of the channel but also its interactions with signaling molecules and its subcellular localization. The gene discussed is KCNMA1; the disease is myotonic dystrophy type 1.