TP53 and rheumatoid arthritis: RA affects up to 1% of adults worldwide.1, 2, 3 FLSs, in particular, are key in RA because they produce cytokines that perpetuate inflammation and proteases.4 Impaired apoptosis of FLSs is mainly the result of abnormal p53 pro-apoptotic signaling that results in changes in the composition and structure of the inflamed synovial membrane.5, 6 These changes cause the development of synovial hyperplasia and extend the life span of these FLSs, facilitating the destruction of cartilage and bone in RA.3, 4, 7