Although echocardiography analysis showed largely decreased ejection fraction (EF) and fractional area change (FAC) in control mice after MI (EF: 67.26±3.148% versus 23.51±3.694%, FAC: 50.9±2.992% versus 15.44 ±2.338%, before and after MI), Nogo-C knockout significantly improved cardiac function after MI to 44.61±4.164% (EF) and 30.49±2.77% (FAC) (Figure 4a). The gene discussed is RTN4; the disease is myocardial infarction.