MiR-182 has been reported to participate in the regulation of multiple physiological and pathological processes including retinal development and degeneration,35, 36 cancers,37, 38, 39, 40 inflammation,41, 42 and cardiac hypertrophy.43 Controversially, miR-182 showed tumor-suppressive function in some cancers such as glioblastoma,44 whereas displayed ongogenic function in other cancers such as lung adenocarcinoma.45 In our study, we found that miR-182 protected cardiomyocytes from Nogo-C and hypoxia-induced apoptosis. Here, RTN4 is linked to lung adenocarcinoma.