Reports on the association of VDR variants with ethnicity, disease or treatment response, VDR DNA methylation and VDR function in South Africans were identified using the PubMed search terms: VDR polymorphism AND South Africa AND (disease OR health OR infection OR infectious OR seasonal OR ethnicity OR pigmentation) OR (seasonal variation AND infectious disease AND polymorphism AND pigmentation AND nutrition). Here, VDR is linked to infectious disease.